It is only when boredom, irrelevance and guilt strike simultaneously that one may begin to wonder: "what exactly am I negotiating for in my life?"
Boredom on its own can usually be dealt with by seeking something that can entertain you. Irrelvance can be effectively tackled away by gaining some form of influence/power, or by a tempting combination of both. Even guilt can be temporarily relieved by doing some form of service to others or by the moral cleansing of the self.
It is the simultaneous attack of those three is what you are probably unable to deal with at the moment? You are likely trying to find out what exactly can you do to evolve out of the harrowing combination of boredom, guilt and irrelevance that has subsumed you. If that is not your reality, what is it that you are trying to look for in this space? This is not a space for idle curiosity.
It is for the high-achiever who is realizing that the BIG Problem is eroding their negotiations. It is stopping them from causing the reality they want. It is for someone who wants to get unstuck.
What is the right way to evolve out of where you are stuck? It may be a bit premature to be given the entire path right away. Perhaps it is best to begin with the right direction for now. A direction that can enable you to see that there is no real overlap between your ethics, wealth and desires at all if the BIG attacks are happening simultaneously.
Ennui, insignificance, and regret can only be experienced simultaneously when there is no overlap between your ethics, economics, and enjoyment at all. They are completely divorced from each other. It is when you see that you are not enjoying the work you are doing, you are not resonating with the mission you are serving and you are not accumulating enough wealth for the kind of load you are bearing, you begin to realize that your dharma, artha, and kama are not at all in harmony. Because even if one of them was working well for you, the B.I.G. attacks could not be simultaneous by definition. They may be arising one by one or one after another but they could not possibly be simultaneous.
Realizing that for the B.I.G. assualt to be truly simultaneous, your ethics, wealth, and desires are not overlapping at all is the first step. Now, that you have the direction, are you willing to move towards negotiating a Total End to the attacks altogether?